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Contents
  • Bone Risks and PHPT
  • Kidney Complications
  • Cardiovascular Concerns

The Hidden Risks of Primary Hyperparathyroidism

The Hidden Risks of Primary Hyperparathyroidism

Why It Matters

Primary hyperparathyroidism (PHPT) is more than just a calcium imbalance; it poses several health risks. Discover the potential complications and risks associated with PHPT.
Contents
  • Bone Risks and PHPT
  • Kidney Complications
  • Cardiovascular Concerns

Bone Risks and PHPT

PHPT can significantly impact bone health, leading to decreased bone mineral density (BMD) and increased fracture risk. Patients with PHPT may experience more severe bone loss at cortical sites like the forearm and hip. While osteitis fibrosa cystica is rare in developed countries, it still occurs in resource-limited regions, highlighting the need for vigilance.

Kidney Complications

One of the most well-known complications of PHPT is nephrolithiasis, or kidney stones, which can occur in up to 55% of patients. Hypercalciuria, or high calcium levels in urine, further increases the risk of stone formation. Subclinical kidney issues, including nephrocalcinosis and chronic kidney insufficiency, can develop silently, necessitating proactive monitoring.
Primary Hyperparathyroidism is a condition characterized by an imbalance of calcium levels in the body due to overactivity of the parathyroid glands, leading to potential bone and kidney complications.

Cardiovascular Concerns

PHPT may be linked to cardiovascular issues such as hypertension and vascular calcification. While the exact causal relationship is not fully understood, studies suggest an association between elevated parathyroid hormone levels and increased vascular stiffness. This potential risk warrants further investigation and monitoring of cardiovascular health in PHPT patients.

FAQs

What bones are most affected by PHPT?

Cortical bones like the forearm and hip are most affected.

How does PHPT affect kidneys?

PHPT can cause kidney stones and other subclinical kidney issues.

Is there a cardiovascular risk with PHPT?

PHPT may be linked to cardiovascular issues like hypertension.

What is nephrolithiasis?

Nephrolithiasis is the formation of kidney stones.

The Bottom Line

Awareness of the risks associated with PHPT can lead to better management and prevention of complications.
Consult with Doctronic to assess your PHPT risk factors today!
Additional References
  1. Silva BC, Cusano NE, Bilezikian JP. Primary hyperparathyroidism. Best Pract Res Clin Endocrinol Metab 2024; 38:101247.
  2. Ejlsmark-Svensson H, Rolighed L, Harsløf T, Rejnmark L. Risk of fractures in primary hyperparathyroidism: a systematic review and meta-analysis. Osteoporos Int 2021; 32:1053.
  3. Peacock M. Primary hyperparathyroidism and the kidney: biochemical and clinical spectrum. J Bone Miner Res 2002; 17 Suppl 2:N87.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic.