Topical vs. Oral Treatments for Onychomycosis: Which is Right for You?
Published: Sep 22, 2023
Choosing the right treatment for onychomycosis can be daunting. Knowing the pros and cons of topical versus oral therapies can guide your decision.
Contents
The Case for Topical Treatments
Topical antifungals, like efinaconazole and ciclopirox, are applied directly to the nail and skin around it. They carry fewer risks of side effects compared to oral medications but may require longer treatment durations. Topicals are ideal for mild cases or for those who cannot take oral medications.
When Oral Treatments Shine
Oral antifungals, such as terbinafine and itraconazole, are often more effective for severe onychomycosis. They work throughout the body, attacking the infection from the inside. However, they can have more side effects and require monitoring, especially for liver health.

Combining Therapies
In some cases, combining oral and topical treatments can enhance results, especially for stubborn infections. This approach may shorten treatment time and reduce the chances of recurrence. Always consult with a healthcare provider before starting combination therapy.
Frequently Asked Questions
Topicals are generally safer with fewer side effects.
Oral treatments are often more effective for severe infections.
Yes, combining treatments may improve results.
Yes, particularly for liver health.
The Bottom Line
Choose your treatment based on infection severity and personal health needs.
References
- Elewski B, et al. J Am Acad Dermatol 2015; 73:62.
- Gupta AK, et al. Clin Dermatol 2013; 31:544.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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