Unraveling the Causes of Antiphospholipid Syndrome
Published: Nov 22, 2023
Antiphospholipid Syndrome (APS) is a complex condition with multiple causes. Understanding these causes can help in predicting and managing the syndrome effectively.
Contents
The Role of Autoimmunity
APS is primarily driven by autoimmunity, where the body attacks its own phospholipid-binding proteins. This misguided immune response leads to an increased risk of blood clots. Autoimmunity in APS is often linked to other diseases like systemic lupus erythematosus (SLE), making it important to monitor autoimmune activity.
Risk Factors to Consider
Certain risk factors can increase the likelihood of developing APS, such as a history of autoimmune diseases. Infections, certain medications, and even genetic predispositions can also play a role. Understanding these risk factors is crucial for early detection and prevention.
APS and Thrombosis
Thrombosis, or blood clot formation, is a key feature of APS. The presence of antiphospholipid antibodies interferes with normal blood clotting processes, leading to either venous or arterial clots. Monitoring blood clotting markers can help in managing and reducing the risk of complications.
Frequently Asked Questions
APS is caused by autoimmune attacks on phospholipid-binding proteins.
Yes, including autoimmune diseases and genetic predispositions.
It leads to abnormal clotting, increasing the risk of thrombosis.
Yes, certain infections may trigger APS.
Key Takeaways
Understanding the causes of APS is vital for early intervention and prevention.
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References
Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 2003; 101:1827.
Pengo V, Ruffatti A, Legnani C, et al. Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. J Thromb Haemost 2010; 8:237.
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