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Contents
  • The Basics of CML
  • Phases of CML
  • Diagnosing CML

What is Chronic Myeloid Leukemia and How Can We Fight It?

What is Chronic Myeloid Leukemia and How Can We Fight It?

Understanding CML

Chronic Myeloid Leukemia (CML) is a type of cancer that affects the blood and bone marrow. This article explores what CML is, how it progresses, and the phases of this disease.
Contents
  • The Basics of CML
  • Phases of CML
  • Diagnosing CML

The Basics of CML

CML is a blood cancer that begins in the bone marrow, where blood cells are made. It's linked to a specific genetic change known as the Philadelphia chromosome, which leads to the creation of an abnormal gene called BCR::ABL1. This gene produces a protein that causes uncontrolled cell growth. CML is unique because it shares features with other myeloproliferative neoplasms (MPNs), like stem cell origin and dysregulated proliferation.

Phases of CML

CML typically progresses through phases, starting with the chronic phase, which is the least aggressive and most common. In this phase, patients may not show symptoms or may have mild symptoms like fatigue or weight loss. If untreated, CML can progress to more severe phases, known as the accelerated and blast phases, characterized by more aggressive symptoms and increased difficulty in treatment.
Chronic Myeloid Leukemia (CML) is a type of cancer that affects the blood and bone marrow. It is associated with the Philadelphia chromosome and progresses through distinct phases.

Diagnosing CML

Diagnosing CML involves looking at the patient's blood and bone marrow to check for the Philadelphia chromosome. Tests like complete blood count (CBC) and polymerase chain reaction (PCR) help confirm the diagnosis. These tests are crucial as they not only confirm CML but also help in monitoring the disease's progression and response to treatment.

FAQs

What causes CML?

CML is caused by a genetic change leading to the Philadelphia chromosome.

How is CML diagnosed?

CML is diagnosed using blood tests and genetic tests for the Philadelphia chromosome.

What are the phases of CML?

CML progresses through chronic, accelerated, and blast phases.

Final Thoughts

Understanding CML is the first step towards effective management and treatment.
Discuss with Doctronic to learn more about CML and its treatment options.
Additional References
  1. Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias. Blood 2022; 140:1200.
  2. Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours. Leukemia 2022; 36:1703.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic.