Decoding Syphilis Tests: What Do They Really Mean?
Published: Aug 03, 2024
Syphilis tests can be confusing, but understanding them is key to proper diagnosis and treatment.
Contents
Types of Tests
Syphilis testing generally involves two types: nontreponemal and treponemal tests. Nontreponemal tests, like RPR and VDRL, are often used for initial screening due to their cost-effectiveness and ease of use. Treponemal tests, such as FTA-ABS and TP-EIA, are more specific and usually confirm syphilis diagnosis.
Reading the Results
A positive result on both tests indicates an active syphilis infection. However, if one test is positive and the other is negative, it may signal a false result or another condition. Consulting a healthcare provider is essential to interpret these results accurately.

False Results Explained
False positives or negatives can occur due to various factors such as pregnancy, autoimmune diseases, or recent vaccinations. If your results seem unexpected, further testing or consultation with a healthcare provider may be necessary.
Frequently Asked Questions
They screen for syphilis by detecting antibodies.
They confirm syphilis-specific antibodies.
Yes, false positives or negatives can occur.
Consult a healthcare provider for guidance.
The Bottom Line
Understanding your syphilis test results can lead to informed health decisions.
References
- Sparling PF. Diagnosis of neurosyphilis: New tools. Sex Transm Dis 2010; 37:288.
- Ghanem KG, Workowski KA. Management of adult syphilis. Clin Infect Dis 2011; 53 Suppl 3:S110.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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