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Contents
  • Estrogen-Only Therapy: The Surprising Findings
  • Combined Therapy: A Different Story
  • The Progestin Factor

Estrogen vs. Estrogen-Progestin: Which Hormone Therapy is Safer?

Estrogen vs. Estrogen-Progestin: Which Hormone Therapy is Safer?

A Tale of Two Therapies

Not all hormone therapies are created equal when it comes to breast cancer risk. This article compares estrogen-only therapy with combined estrogen-progestin therapy, revealing important differences in their safety profiles.
Contents
  • Estrogen-Only Therapy: The Surprising Findings
  • Combined Therapy: A Different Story
  • The Progestin Factor

Estrogen-Only Therapy: The Surprising Findings

Contrary to what many might expect, estrogen-only therapy hasn't been linked to increased breast cancer risk in short-term use. The Women's Health Initiative (WHI) study found that women using estrogen alone for an average of 5.9 years actually had a slightly lower risk of breast cancer. This is reassuring news for women who've had a hysterectomy and are considering estrogen therapy for menopause symptoms.

Combined Therapy: A Different Story

Combined estrogen-progestin therapy, however, does increase breast cancer risk. The WHI study found that women using this therapy had about 8 extra cases of breast cancer per 10,000 person-years of use. The risk became apparent after about 3-4 years of use. This difference highlights the important role that progestins play in breast cancer risk.
This study compares the breast cancer risk associated with estrogen-only therapy versus combined estrogen-progestin therapy.

The Progestin Factor

The addition of progestin to estrogen therapy seems to be the key factor in increased breast cancer risk. Some studies suggest that different types of progestins may have different risk profiles. For example, natural progesterone might have a lower risk than synthetic progestins, though more research is needed. The way progestin is given (continuously or cyclically) may also affect risk, but findings are inconsistent.

FAQs

Why do some women need progestin?

To protect the uterus from estrogen-related cancer risk.

Can all women use estrogen-only therapy?

No, it's typically only for women without a uterus.

Are there alternatives to progestins?

Some non-hormonal options exist; discuss with your doctor.

Does the form of estrogen matter?

Possibly, but more research is needed on different types.

How do I choose between therapies?

Consider your individual health profile and risk factors.

The Key Takeaway

While estrogen-only therapy appears safer regarding breast cancer risk, the choice between therapies depends on individual health factors and needs.
Consult with Doctronic to determine which hormone therapy option, if any, is best suited for your unique health profile and menopause symptoms.
Additional References
  1. Manson JE, et al. JAMA 2013; 310:1353.
  2. Chlebowski RT, et al. JAMA Oncol 2015; 1:296.
  3. Fournier A, et al. Breast Cancer Res Treat 2008; 107:103.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic.