What's the Deal with 5-Alpha Reductase Inhibitors?
What's the Deal with 5-Alpha Reductase Inhibitors?
Understanding the Approach
5-alpha reductase inhibitors (5-ARIs) are a key treatment for BPH. Learn how they work and who benefits most.
Contents
- How 5-ARIs Work
- Efficacy and Use
- Potential Side Effects
How 5-ARIs Work
5-ARIs reduce the size of an enlarged prostate by blocking hormones that cause growth. This can improve urinary symptoms and reduce the need for surgery. Common 5-ARIs include finasteride and dutasteride.
Efficacy and Use
5-ARIs are effective in men with significantly enlarged prostates. They lower prostate volume and slow disease progression, minimizing the risk of acute urinary retention. These benefits make them crucial in long-term BPH management.
Potential Side Effects
Side effects of 5-ARIs can include sexual dysfunction and decreased libido. Some patients report persistent symptoms even after stopping the medication. It's important to discuss these potential impacts with a healthcare provider.
FAQs
What do 5-ARIs do?
5-ARIs shrink the prostate by blocking growth hormones.
Who benefits from 5-ARIs?
Men with significantly enlarged prostates see the most benefit.
Are there side effects?
Yes, possible side effects include sexual dysfunction.
How long do they take to work?
They may take several months for full effect.
Wrapping Up
5-ARIs are vital for managing BPH but require a careful look at potential side effects.
Additional References
- Nickel JC, Gilling P, Tammela TL, et al. EPICS study. BJU Int 2011; 108:388.
- McConnell JD, Roehrborn CG, Bruskewitz R, et al. N Engl J Med 1998; 338:557.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic.